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[11C]Methylenetriphenylphosphorane, a new 11C-precursor, used in a one-pot wittig synthesis of [β-11C]styrene

✍ Scribed by Tor Kihlberg; Per Gullberg; Bengt Långström

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
299 KB
Volume
28
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Preparation of [^11^C]methyltriphenylphosphonium iodide and the in situ generation of [^11^C]methylenetriphenylphosphorane directly from [^11^C]methyl iodide, is described. Using this one‐pot preparation, [β‐^11^C]styrene was synthesized conveniently, fast and with a minimum of manual handling. The synthesis was performed by using [^11^C]methyl iodide, triphenylphosphine, epichlorohydrin and benzaldehyde in tetrahydrofurane/o‐dibromobenzene, with a synthesis time of 40 min (counted from the end of [^11^C]methyl iodide transfer), a radiochemical yield of 80–90% of [β‐^11^C]styrene and a specific radioactivity, of 100MBq/μmol. In a typical experiment starting with 960 MBq ^11^C‐methyl iodide, 200 MBq of [β‐^11^C]styrene was obtained within 42 min.

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