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Unsaturated phosphinic analogues of γ-aminobutyric acid as GABAC receptor antagonists

✍ Scribed by Mary Chebib; Robert J. Vandenberg; Wolfgang Froestl; Graham A.R. Johnston

Book ID
119414544
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
686 KB
Volume
329
Category
Article
ISSN
0014-2999

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Phosphinic acid analogues of γ-aminobuty
Phosphinic acid analogues of γ-aminobutyric acid (GABA). Synthesis of a new radioligand
✍ Roger G. Hall; Peter D. Kane; Helmut Bittiger; Wolfgang Froestl 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 252 KB

## Abstract The synthesis of a new radioligand, which binds with high selectivity and affinity (K~D~ = 7.4 nM) to the GABA‐B receptor, is described. A Wittig‐Horner approach was employed to prepare an unsaturated protected intermediate (6), suitable for tritiation and deprotection.