## 23 -107 2,6-Difluorophenol as a Bioisostere of a Carboxylic Acid: Bioisosteric Analogues of γ-Aminobutyric Acid. -Compounds (VII) and (X) are synthesized in 9 and 5 steps., resp., starting from difluorophenol (I). Iodination of aniline (II) gives only one product (III) in contrast to brominatio
✦ LIBER ✦
2,6-Difluorophenol as a Bioisostere of a Carboxylic Acid: Bioisosteric Analogues of γ-Aminobutyric Acid
✍ Scribed by Qiu, Jian; Stevenson, Scott H.; O'Beirn, Michael J.; Silverman, Richard B.
- Book ID
- 127013061
- Publisher
- American Chemical Society
- Year
- 1999
- Tongue
- English
- Weight
- 97 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0022-2623
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
ChemInform Abstract: 2,6-Difluorophenol
✍
Jian Qiu; Scott H. Stevenseon; Michael J. O'Beirne; Richard B. Silverman
📂
Article
📅
2010
🏛
John Wiley and Sons
⚖ 33 KB
👁 2 views
Pyrrolines as Prodrugs of γ-Aminobutyric
✍
Patrick S. Callery; Linda A. Geelhaar; M. S. Balachandran Nayar; Martin Stogniew
📂
Article
📅
1982
🏛
John Wiley and Sons
🌐
English
⚖ 535 KB
Synthesis and Functionalization of Cycli
✍
Pemberton, Nils; Graden, Henrik; Evertsson, Emma; Bratt, Emma; Lepistö, Matti; J
📂
Article
📅
2012
🏛
American Chemical Society
🌐
English
⚖ 726 KB
Carboxylic acid bioisosteres of γ-linked
✍
Vassilios Bavetsias; Ann L. Jackman; Rosemary Kimbell; F. Thomas Boyle; Graham M
📂
Article
📅
1996
🏛
Elsevier Science
🌐
English
⚖ 273 KB
ChemInform Abstract: Synthesis of γ-Amin
✍
Jane R. Hanrahan; Graham A. R. Johnston
📂
Article
📅
2010
🏛
John Wiley and Sons
⚖ 16 KB
👁 1 views
Phosphinic acid analogues of γ-aminobuty
✍
Roger G. Hall; Peter D. Kane; Helmut Bittiger; Wolfgang Froestl
📂
Article
📅
1995
🏛
John Wiley and Sons
🌐
French
⚖ 252 KB
## Abstract The synthesis of a new radioligand, which binds with high selectivity and affinity (K~D~ = 7.4 nM) to the GABA‐B receptor, is described. A Wittig‐Horner approach was employed to prepare an unsaturated protected intermediate (6), suitable for tritiation and deprotection.