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Phosphinic acid analogues of γ-aminobutyric acid (GABA). Synthesis of a new radioligand

✍ Scribed by Roger G. Hall; Peter D. Kane; Helmut Bittiger; Wolfgang Froestl

Publisher
John Wiley and Sons
Year
1995
Tongue
French
Weight
252 KB
Volume
36
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The synthesis of a new radioligand, which binds with high selectivity and affinity (K~D~ = 7.4 nM) to the GABA‐B receptor, is described. A Wittig‐Horner approach was employed to prepare an unsaturated protected intermediate (6), suitable for tritiation and deprotection.

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ChemInform Abstract: A Simple and Effici
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A Simple and Efficient Synthesis of γ-Aminobutyric Acid (GABA) Derivatives. -The phase-transfer catalyzed reaction of N-(benzylidene)benzylamine (I) with some esters of cinnamic acid (II) offers a convenient and efficient route for the preparation of GABA derivatives (IV) (6 examples). -(DRYANSKA,