ChemInform Abstract: Piperidinyl-3-phosphinic Acids as Novel Uptake Inhibitors of the Neurotransmitter γ-Aminobutyric Acid (GABA).
✍ Scribed by Jan Kehler; Tine B. Stensboel; Povl Krogsgaard-Larsen
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 34 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0931-7597
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Syntheses of Novel Piperidin-4-ylphosphinic Acid, and Piperidin-4-ylphosphonic Acid Analogues of the Inhibitory Neurotransmitter 4-Aminobutyric Acid (GABA). -The novel acids (V)-(VIII) are synthesized utilizing a sequential Pudovik addition followed by a modified Barton deoxygenation and acidic hydr
Synthesis of 4,4-Bis(2-methylphenyl)-3-butenyl (and butyl) Analogues of 4-Phenyl-1,4,-and 6-Phenyl-1,6-dihydropyridine-3-carboxylic Acids and Their Evaluation as Neuronal GABA-Uptake Inhibitors. -All attempts to hydrolyze the esters (VIII) and (IX) to a carboxyl group result in decomposition product
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