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ChemInform Abstract: Syntheses of Novel Piperidin-4-ylphosphinic Acid, and Piperidin-4-ylphosphonic Acid Analogues of the Inhibitory Neurotransmitter 4-Aminobutyric Acid (GABA).

✍ Scribed by J. KEHLER; B. EBERT; O. DAHL; P. KROGSGAARD-LARSEN

Publisher: John Wiley and Sons
Year: 2010
Weight: 30 KB
Volume: 30
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199911219

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✦ Synopsis

Syntheses of Novel Piperidin-4-ylphosphinic Acid, and Piperidin-4-ylphosphonic Acid Analogues of the Inhibitory Neurotransmitter 4-Aminobutyric Acid (GABA). -The novel acids (V)-(VIII) are synthesized utilizing a sequential Pudovik addition followed by a modified Barton deoxygenation and acidic hydrolysis. The target amino acids are obtained in good yields by this mild procedure. -(KEHLER,

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