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Application of Polymer-Supported Enzymes and Reagents in the Synthesis of γ-Aminobutyric Acid (GABA) Analogues.

✍ Scribed by Ian R. Baxendale; Martin Ernst; Wolf-Ruediger Krahnert; Steven V. Ley


Publisher
John Wiley and Sons
Year
2003
Weight
135 KB
Volume
34
Category
Article
ISSN
0931-7597

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Phosphinic acid analogues of γ-aminobuty
✍ Roger G. Hall; Peter D. Kane; Helmut Bittiger; Wolfgang Froestl 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 252 KB

## Abstract The synthesis of a new radioligand, which binds with high selectivity and affinity (K~D~ = 7.4 nM) to the GABA‐B receptor, is described. A Wittig‐Horner approach was employed to prepare an unsaturated protected intermediate (6), suitable for tritiation and deprotection.