Phosphinic acid analogues of γ-aminobuty
✍
Roger G. Hall; Peter D. Kane; Helmut Bittiger; Wolfgang Froestl
📂
Article
📅
1995
🏛
John Wiley and Sons
🌐
French
⚖ 252 KB
## Abstract The synthesis of a new radioligand, which binds with high selectivity and affinity (K~D~ = 7.4 nM) to the GABA‐B receptor, is described. A Wittig‐Horner approach was employed to prepare an unsaturated protected intermediate (6), suitable for tritiation and deprotection.