Analogues of γ-aminobutyric acid (GABA) and trans-4-aminocrotonic acid (TACA) substituted in the 2 position as GABAC receptor antagonists

The synthesis of 4-(4-([11C]methoxypheny

The synthesis of 4-(4-([11C]methoxyphenyl) -(5-fluoro-2-hydro-xyphenyl)-methylene-aminobutyric acid, as a potential radioli-gand for the gaba receptor in the brain

✍ Filip De Vos; Guido Slegers 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 485 KB

## Abstract A procedure for the synthesis of 4‐(4‐[^11^C]methoxyphenyl) ‐(5‐fluoro‐2‐hydroxyphenyl)‐methylene‐aminobutyric acid has been developed. The production entailed a O‐methylation of 5‐fluoro‐2‐hydroxy‐4′‐hydroxybenzophenone with cyclotron produced [^11^C]iodomethane in the presence of alka