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Un nouvel analogue synthétique de l'adénosine: La désoxy-3′-C-dibromométhylidène-3′-adénosine

✍ Scribed by Jean M. J. Tronchet; Dominique Schwarzenbach

Publisher
John Wiley and Sons
Year
1977
Tongue
German
Weight
356 KB
Volume
60
Category
Article
ISSN
0018-019X

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✦ Synopsis

A novel synthetic analog of adenosine: the 3′‐deoxy‐3′‐C‐dibromomenthylidene‐adenosine

The title compound (7) has been prepared by a sequence of classical synthetic steps from 3‐deoxy‐3‐C‐dibromomethylidene‐1,2: 5,6‐di‐O‐isopropylidene‐α‐D‐ribo‐hexofuranose (1). The β‐configuration of the nucleoside was established by formation of a cyclonucleoside. 7 is very slowly deaminated by adenosine deaminase. In contrast with its dichloro analog, it does not inhibit the growth of Escherichia coli.

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