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Un nouvel exemple de nucléoside à sucre ramifié insaturé: la désoxy-3′-méthylidène-3′-adénosine

✍ Scribed by Jean M. J. Tronchet; Jeannine F. Tronchet

Publisher
John Wiley and Sons
Year
1981
Tongue
German
Weight
303 KB
Volume
64
Category
Article
ISSN
0018-019X

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✦ Synopsis

A Novel Example of Unsaturated Branched‐chain Sugar Nucleoside: 3′‐Deoxy‐3′‐methylidene‐adenosine

Starting from 5‐O‐benzoyl‐3‐C‐methylidene‐3‐deoxy‐1,2‐O‐isopropylidene‐α‐D‐erythro‐pentofuranose (11) the title compound 8 has been prepared. Its α‐anomer (9) and the acyclic sugar nucleoside 10 have been obtained as by‐products. Adenosine deaminase slowly deaminated 8, 9 being not affected. Compound 8 exhibited no antiviral activity, whereas one of its saturated analogues (13) inhibited the multiplication of the herpes‐1 (HF) virus.

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