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Ultrafast Grignard addition reactions in the presence of water

✍ Scribed by Osztrovszky, Gyorgyi; Holm, Torkil; Madsen, Robert

Book ID
120495460
Publisher
Royal Society of Chemistry
Year
2010
Tongue
English
Weight
97 KB
Volume
8
Category
Article
ISSN
1477-0520

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## Abstract The reactivity in the normal Grignard addition reaction is greatly reduced when the ketone is branched in the α‐position. Alkylation in β‐position has only slight effect and in the γ‐position there is no effect at all.