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UGT1A1 polymorphism predicts irinotecan toxicity: Evolving proof

✍ Scribed by Mani, Sridhar

Book ID: 118728943
Publisher: Springer US
Year: 2001
Tongue: English
Weight: 42 KB
Volume: 3
Category: Article
ISSN: 1530-9932
DOI: 10.1208/ps0303_commentary2

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## Abstract ## BACKGROUND It is known that the uridine‐diphosphoglucuronosyl transferase 1A1 (UGT1A1)\*28 polymorphism reduces UGT1A1 enzyme activity, which may lead to severe toxicities in patients who receive irinotecan. This study was conducted to assess the influence of this polymorphism on th