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UGT1A1 Polymorphism Can Predict Hematologic Toxicity in Patients Treated with Irinotecan

✍ Scribed by Cote, J.-F.; Kirzin, S.; Kramar, A.; Mosnier, J.-F.; Diebold, M.-D.; Soubeyran, I.; Thirouard, A.-S.; Selves, J.; Laurent-Puig, P.; Ychou, M.

Book ID
111972162
Publisher
American Association for Cancer Research
Year
2007
Tongue
English
Weight
251 KB
Volume
13
Category
Article
ISSN
1078-0432

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## Abstract ## BACKGROUND It is known that the uridine‐diphosphoglucuronosyl transferase 1A1 (UGT1A1)\*28 polymorphism reduces UGT1A1 enzyme activity, which may lead to severe toxicities in patients who receive irinotecan. This study was conducted to assess the influence of this polymorphism on th