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UGT1A1*28 genotype predicts gastrointestinal toxicity in patients treated with intermediate-dose irinotecan

✍ Scribed by Ferraldeschi, Roberta; Minchell, Laura J; Roberts, Stephen A; Tobi, Simon; Hadfield, Kristen D; Blackhall, Fiona H; Mullamitha, Saifee; Wilson, Gregory; Valle, Juan; Saunders, Mark; Newman, William G

Book ID: 120185256
Publisher: Future Medicine
Year: 2009
Tongue: English
Weight: 363 KB
Volume: 10
Category: Article
ISSN: 1462-2416
DOI: 10.2217/pgs.09.20

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## Abstract ## BACKGROUND It is known that the uridine‐diphosphoglucuronosyl transferase 1A1 (UGT1A1)\*28 polymorphism reduces UGT1A1 enzyme activity, which may lead to severe toxicities in patients who receive irinotecan. This study was conducted to assess the influence of this polymorphism on th