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524 POSTER UGT1A1*28 polymorphism is not associated to irinotecan-induced toxicity in pediatric patients

✍ Scribed by C. de Torres; O. Cruz; A. Parareda; S. Segura; J. Mora


Book ID
118625305
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
62 KB
Volume
5
Category
Article
ISSN
1359-6349

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UGT1A1*28 polymorphism predicts irinotec
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## Abstract ## BACKGROUND It is known that the uridine‐diphosphoglucuronosyl transferase 1A1 (UGT1A1)\*28 polymorphism reduces UGT1A1 enzyme activity, which may lead to severe toxicities in patients who receive irinotecan. This study was conducted to assess the influence of this polymorphism on th