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UGT1A16/28 polymorphisms could predict irinotecan-induced severe neutropenia not diarrhea in Chinese colorectal cancer patients

✍ Scribed by Jing Gao, Jun Zhou, Yanyan Li, Ming Lu, Ru Jia, Lin Shen

Book ID: 120899714
Publisher: Springer US
Year: 2013
Tongue: English
Weight: 272 KB
Volume: 30
Category: Article
ISSN: 1357-0560
DOI: 10.1007/s12032-013-0604-x

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## Abstract ## BACKGROUND It is known that the uridine‐diphosphoglucuronosyl transferase 1A1 (UGT1A1)\*28 polymorphism reduces UGT1A1 enzyme activity, which may lead to severe toxicities in patients who receive irinotecan. This study was conducted to assess the influence of this polymorphism on th

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