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Ubiquitin Proteasome System in Stress and Disease

✍ Scribed by Karpov, Dmitry; Glickman, Michael H.; Bar-Nun, Shoshana; Coffino, Philip

Book ID
120174900
Publisher
Hindawi Limited
Year
2012
Tongue
English
Weight
420 KB
Volume
2012
Category
Article
ISSN
2090-2247

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## Abstract Increasing genetic, pathological, and experimental evidence suggest that neurodegeneration in both familial and sporadic forms of Parkinson's disease (PD) may be related to a defect in the capacity of the ubiquitin–proteasome system (UPS) to clear unwanted proteins, resulting in protein