E3 ubiquitin ligases in T-cell tolerance
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Magdalena Paolino; Josef M. Penninger
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Article
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2009
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John Wiley and Sons
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English
β 189 KB
## Abstract The immune system uses several mechanisms of central and peripheral tolerance in order to prevent the activation of T lymphocytes toward selfβantigens. Although the importance of immune selfβtolerance has been established for a long time, some essential cellular and molecular mechanisms