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The E3 ubiquitin ligase Itch in T cell activation, differentiation, and tolerance

✍ Scribed by Yun-Cai Liu


Book ID
116885489
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
277 KB
Volume
19
Category
Article
ISSN
1044-5323

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## Abstract The immune system uses several mechanisms of central and peripheral tolerance in order to prevent the activation of T lymphocytes toward self‐antigens. Although the importance of immune self‐tolerance has been established for a long time, some essential cellular and molecular mechanisms