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E3 ubiquitin ligases in T-cell tolerance

✍ Scribed by Magdalena Paolino; Josef M. Penninger

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
189 KB
Volume
39
Category
Article
ISSN
0014-2980

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✦ Synopsis

Abstract

The immune system uses several mechanisms of central and peripheral tolerance in order to prevent the activation of T lymphocytes toward self‐antigens. Although the importance of immune self‐tolerance has been established for a long time, some essential cellular and molecular mechanisms of T‐cell tolerance have only been recently revealed. Once thought to be a recycling system, protein ubiquitylation by E3 ligases has now emerged as a regulated and crucial modulator of immune responses, and more importantly as a key signaling pathway involved in T‐cell tolerance. In this review, we highlight our current understanding of the transcriptional and molecular signaling mechanisms involved in ubiquitylation‐mediated T‐cell tolerance.

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