Two subclones in a case of uveal melanoma: Relevance of monosomy 3 and multiplication of chromosome 8q
β Scribed by Gabriele Prescher; Norbert Bornfeld; Reinhard Becher
- Book ID
- 119106220
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 243 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0165-4608
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Posterior uveal melanomas have nonrandom alterations affecting chromosomes 3, 6, and 8. Loss of chromosome 3 in uveal melanoma has been shown to act as a predictor of disease-free and overall survival. To confirm the significance of chromosome 3 loss and to extend the observations to include those o
## Abstract Six posterior uveal melanomas were karyotyped after shortβterm culture. One had a normal chromosome complement; the remaining five had limited chromosome changes. Involvement of chromosomes 1 and 6 was noted in two and four cases, respectively, and three ciliary body tumours demonstrate