Recent computational studies of alkane hydroxylation and alkene epoxidation by a model active species of the enzyme cytochrome P-450 reveal a two-state reactivity (TSR) scenario in which the information content of the product distribution is determined jointly by two states. TSR is used to reconcile
โฆ LIBER โฆ
Two States and Two More in the Mechanisms of Hydroxylation and Epoxidation by Cytochrome P450
โ Scribed by Hirao, Hajime; Kumar, Devesh; Thiel, Walter; Shaik, Sason
- Book ID
- 120969027
- Publisher
- American Chemical Society
- Year
- 2005
- Tongue
- English
- Weight
- 644 KB
- Volume
- 127
- Category
- Article
- ISSN
- 0002-7863
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Alkane hydroxylation [1] by cytochrome P-450 poses tantalizing mechanistic questions. The consensus rebound mechanism, Scheme 1, [2] involves hydrogen abstraction from the Scheme 1. Schematic representation of the rebound mechanism.