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Aromatic Hydroxylation by Cytochrome P450: Model Calculations of Mechanism and Substituent Effects

✍ Scribed by Bathelt, Christine M.; Ridder, Lars; Mulholland, Adrian J.; Harvey, Jeremy N.


Book ID
121272819
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
112 KB
Volume
125
Category
Article
ISSN
0002-7863

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The study of haemin-catalysed oxidation reactions was extended to substituted aromatic rings. Both electron-donating and electron-withdrawing substituents on aromatic rings act as para- and meta-directing agents in the presence of tetrakis(2,6-dichlorophenyl)porphyrin iron(III) chloride as catalyst