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Mechanism and structure?reactivity relationships for aromatic hydroxylation by cytochrome P450

✍ Scribed by Bathelt, Christine M.; Ridder, Lars; Mulholland, Adrian J.; Harvey, Jeremy N.


Book ID
127396281
Publisher
Royal Society of Chemistry
Year
2004
Tongue
English
Weight
314 KB
Volume
2
Category
Article
ISSN
1477-0520

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Two-state reactivity mechanisms of hydro
✍ Sason Shaik; SamuΓ«l P de Visser; FranΓ§ois Ogliaro; Helmut Schwarz; Detlef SchrΓΆd πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 English βš– 199 KB

Recent computational studies of alkane hydroxylation and alkene epoxidation by a model active species of the enzyme cytochrome P-450 reveal a two-state reactivity (TSR) scenario in which the information content of the product distribution is determined jointly by two states. TSR is used to reconcile