Two-State Reactivity in the Rebound Step of Alkane Hydroxylation by Cytochrome P-450: Origins of Free Radicals with Finite Lifetimes

✍ Scribed by Nathan Harris; Shimrit Cohen; Michael Filatov; François Ogliaro; Sason Shaik

• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 119 KB
• Volume: 39
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/1521-3773(20000602)39:11<2003::aid-anie2003>3.0.co;2-m

✦ Synopsis

Alkane hydroxylation [1] by cytochrome P-450 poses tantalizing mechanistic questions. The consensus rebound mechanism, Scheme 1, [2] involves hydrogen abstraction from the Scheme 1. Schematic representation of the rebound mechanism.