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On the “Rebound” Mechanism of Alkane Hydroxylation by Cytochrome P450: Electronic Structure of the Intermediate and the Electron Transfer Character in the Rebound Step

✍ Scribed by Michael Filatov; Nathan Harris; Sason Shaik


Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
85 KB
Volume
38
Category
Article
ISSN
0044-8249

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Two-State Reactivity in the Rebound Step
✍ Nathan Harris; Shimrit Cohen; Michael Filatov; François Ogliaro; Sason Shaik 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 119 KB 👁 1 views

Alkane hydroxylation [1] by cytochrome P-450 poses tantalizing mechanistic questions. The consensus rebound mechanism, Scheme 1, [2] involves hydrogen abstraction from the Scheme 1. Schematic representation of the rebound mechanism.