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The “Rebound Controversy”: An Overview and Theoretical Modeling of the Rebound Step in C−H Hydroxylation by Cytochrome P450

✍ Scribed by Sason Shaik; Shimrit Cohen; Samuël P. de Visser; Pankaz K. Sharma; Devesh Kumar; Sebastian Kozuch; François Ogliaro; David Danovich


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
441 KB
Volume
2004
Category
Article
ISSN
1434-1948

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Two-State Reactivity in the Rebound Step
✍ Nathan Harris; Shimrit Cohen; Michael Filatov; François Ogliaro; Sason Shaik 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 119 KB 👁 1 views

Alkane hydroxylation [1] by cytochrome P-450 poses tantalizing mechanistic questions. The consensus rebound mechanism, Scheme 1, [2] involves hydrogen abstraction from the Scheme 1. Schematic representation of the rebound mechanism.