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Two-directional chain synthesis: an application to the synthesis of (+)-mycoticin A

โœ Scribed by Poss, Christopher S.; Rychnovsky, Scott D.; Schreiber, Stuart L.


Book ID
118262961
Publisher
American Chemical Society
Year
1993
Tongue
English
Weight
249 KB
Volume
115
Category
Article
ISSN
0002-7863

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Stereoselective synthesis of an isomer o
โœ Michael V. Perkins; Rebecca A. Sampson ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 271 KB

An isomer of Membrenone-C was prepared in 8 steps (17% yielu) with 93% overall ds starting from the ethyl ketone (S)-10. Key steps are the boron-mediated aldol followed by anti selective reduction, giving the C6-C10 stereochemistry, the two direction chain extending double titanium aldol coupling, 1