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Two-Directional Synthesis of Polycyclopropanes. An Approach to the Quinquecyclopropane Fragment of U-106305

✍ Scribed by McDonald, W. Scott; Verbicky, Christopher A.; Zercher, Charles K.


Book ID
118038802
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
320 KB
Volume
62
Category
Article
ISSN
0022-3263

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## Abstract The isotopically labelled __C__‐terminal fragment of zervamicin, H‐Hyp^10^‐[4,4‐^2^H~2~‐Gln]‐Aib‐Hyp‐Aib‐Pro‐Phl^16^, has been synthesized in solution by a Fmoc/__tert__‐butyl strategy in 28% overall yield. The Fmoc group was removed by reaction for 2 min with 0.1 M NaOH in dioxane/meth