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Application of the two-directional chain synthesis strategy to the first stereochemical assignment of structure to members of the skipped-polyol polyene macrolide class: mycoticin A and B

โœ Scribed by Schreiber, Stuart L.; Goulet, Mark T.


Book ID
126871387
Publisher
American Chemical Society
Year
1987
Tongue
English
Weight
312 KB
Volume
109
Category
Article
ISSN
0002-7863

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Stereochemical studies of the skipped-po
โœ Stuart L. Schreiber; Mark T. Goulet ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 323 KB

The degradation of prototype members of the skipped-polyol polyene macrolide class, mycoticins A and B, is reported. The characterization of the resultant fragments allows a partial structure determination to be achieved. The polyene macrolides comprise a large class of natural products which displ

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The tetraformylal derivative of mycoticin A and B 2 has been prepared in high yield from the natural products 1. 2-D COSY NMR and NOEDS experiments allow assignment of all nonequivalent hydrogens in 2. NOE difference experiments shed light on the relative stereochemistry and conformation of the skip