The degradation of prototype members of the skipped-polyol polyene macrolide class, mycoticins A and B, is reported. The characterization of the resultant fragments allows a partial structure determination to be achieved. The polyene macrolides comprise a large class of natural products which displ
โฆ LIBER โฆ
Application of the two-directional chain synthesis strategy to the first stereochemical assignment of structure to members of the skipped-polyol polyene macrolide class: mycoticin A and B
โ Scribed by Schreiber, Stuart L.; Goulet, Mark T.
- Book ID
- 126871387
- Publisher
- American Chemical Society
- Year
- 1987
- Tongue
- English
- Weight
- 312 KB
- Volume
- 109
- Category
- Article
- ISSN
- 0002-7863
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The tetraformylal derivative of mycoticin A and B 2 has been prepared in high yield from the natural products 1. 2-D COSY NMR and NOEDS experiments allow assignment of all nonequivalent hydrogens in 2. NOE difference experiments shed light on the relative stereochemistry and conformation of the skip