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Studies relating to the synthesis of the immunosuppressive agent FK-506: application of the two-directional chain synthesis strategy to the pyranose moiety

โœ Scribed by Schreiber, Stuart L.; Sammakia, Tarek; Uehling, David E.


Book ID
118262998
Publisher
American Chemical Society
Year
1989
Tongue
English
Weight
218 KB
Volume
54
Category
Article
ISSN
0022-3263

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Studies relating to the immunosuppressiv
โœ M. Furber; M.E. Cooper; D.K. Donald ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 187 KB

Beckmann rearrangement of FK506 E-oxime gave amide 2 and the fragmentation product 4. Compound 4 was atso prepared by total synthesis. The immunosuppressant FK506 has been the subject of considerabie synthetic' and degradative2 studies. As part of our pmgramme in this area we investigated the stNdU