Tumour-specific transplantation antigen from SV40 transformed cells binds to DNA
✍ Scribed by CHANG, CHUNGMING; LUBORSKY, SAMUEL W.; MORA, PETER T.
- Book ID
- 109707240
- Publisher
- Nature Publishing Group
- Year
- 1977
- Tongue
- English
- Weight
- 391 KB
- Volume
- 269
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/269438a0
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## Abstract Specific cell‐mediated immunity to SV40 tumor‐specific transplantation antigen (TSTA) in BALB/c mice undergoing progressive tumorigenesis by syngeneic SV40‐transformed cells (VLM) was investigated in vivo using a tumor‐cell neutralization test. Specific cellular reactivity to SV40 TSTA
## Abstract The effect of immunization with fetal antigens and tumor‐specific antigens on the transplantation of SVT2, a BALB/c mouse tumor induced by Simian virus 40 (SV40), has been studied. Hyperimmunization with 5,000 R X‐irradiated, syngeneic fetuses of 1–2 weeks' gestation or syngeneic spleen
## Abstract A solubilization technique employing 0.5% Triton X‐100 was developed to obtain both SV40 virus (SV40)‐induced tumor‐specific surface antigen(s) (TSSA) from SV40‐transformed mouse cells, as determined by a serum‐mediated microcytolytic assay, and tumor‐specific transplantation antigen(s)