SV40 Virus-induced Tumour Specific Transplantation Antigen in Cultured Mouse Cells
✍ Scribed by SMITH, RICHARD W.; MORGANROTH, JOEL; MORA, PETER T.
- Book ID
- 109674266
- Publisher
- Nature Publishing Group
- Year
- 1970
- Tongue
- English
- Weight
- 606 KB
- Volume
- 227
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/227141a0
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Hamster lymphocyte leukemia and lymphosarcoma induced in vivo __by papova‐virus SV40 were tested for the presence of SV40‐specific transplantation antigen. The cells derived from lymphocytic leukemia (GD‐248) blocked primary SV40 oncogenesis__ in vivo and also immunized adult hamsters a
## Abstract A solubilization technique employing 0.5% Triton X‐100 was developed to obtain both SV40 virus (SV40)‐induced tumor‐specific surface antigen(s) (TSSA) from SV40‐transformed mouse cells, as determined by a serum‐mediated microcytolytic assay, and tumor‐specific transplantation antigen(s)
Highly purified vesicular stomatitis virus (VSV) was obtained from VSV-infected SV40-transformed and from "normal" hamster cell lines. A glycolipid extract was prepared from these VSV preparations according to the Folch partition procedure. These glycolipids were rendered immunogenic to the Syrian h
## Abstract Marked differences in the manifestation of SV40‐specific surface (S‐) antigen were found between hamster cell lines transformed __in vitro__ and __in vivo__ by SV40 and UV‐irradiated or photodynamically inactivated SV40. In the mixed hemagglutination reaction (MHA) cell lines induced by
## Abstract “Spontaneously” or SV40 virus transformed AL/N mouse cell lines were passed repeatedly through syngeneic mice. Cell lines were re‐established in culture from minced pieces of tumors in the presence of concentrated fetal calf serum or from tumor cells dispersed by trypsin. The aim of thi