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Tryptophan-replacement and indole-modified apicidins: synthesis of potent and selective antiprotozoal agents

โœ Scribed by Steven L Colletti; Chunshi Li; Michael H Fisher; Matthew J Wyvratt; Peter T Meinke

Book ID
104210914
Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
113 KB
Volume
41
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

A ruthenium tetraoxide catalyzed degradation of apicidin's tryptophan indole provided access to two useful carboxylic acid homolog intermediates. The synthesis of a series of potent and/or selective ketone homologs and 2-arylindoles derived from apicidin is described.

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