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Synthesis of Apicidin-Derived Quinolone Derivatives: Parasite-Selective Histone Deacetylase Inhibitors and Antiproliferative Agents

โœ Scribed by Meinke, Peter T.; Colletti, Steven L.; Doss, George; Myers, Robert W.; Gurnett, Anne M.; Dulski, Paula M.; Darkin-Rattray, Sandra J.; Allocco, John J.; Galuska, Stefan; Schmatz, Dennis M.


Book ID
111980141
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
52 KB
Volume
43
Category
Article
ISSN
0022-2623

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Synthesis of side chain modified apicidi
โœ Peter T Meinke; Steven L Colletti; Michelle B Ayer; Sandra J Darkin-Rattray; Rob ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 87 KB

An efficient degradation of apicidin's ketone-containing side chain to two common intermediates (the C7-aldehyde and the C8-methyl ester) is described. From these intermediates, a series of potent mechanism-based histone deacetylase inhibitors was prepared to facilitate biochemical studies.