Synthesis of side chain modified apicidi
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Peter T Meinke; Steven L Colletti; Michelle B Ayer; Sandra J Darkin-Rattray; Rob
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Article
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2000
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Elsevier Science
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French
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An efficient degradation of apicidin's ketone-containing side chain to two common intermediates (the C7-aldehyde and the C8-methyl ester) is described. From these intermediates, a series of potent mechanism-based histone deacetylase inhibitors was prepared to facilitate biochemical studies.