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Novel amide derivatives as inhibitors of histone deacetylase: Design, synthesis and SAR

✍ Scribed by Victor Andrianov; Vija Gailite; Daina Lola; Einars Loza; Valentina Semenikhina; Ivars Kalvinsh; Paul Finn; Kamille Dumong Petersen; James W.A. Ritchie; Nagma Khan; Anthony Tumber; Laura S. Collins; Sree M. Vadlamudi; Fredrik Björkling; Maxwell Sehested

Book ID
108116179
Publisher
Elsevier Science
Year
2009
Tongue
French
Weight
920 KB
Volume
44
Category
Article
ISSN
0223-5234

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Novel Sulfonamide Derivatives as Inhibit
Novel Sulfonamide Derivatives as Inhibitors of Histone Deacetylase
✍ Paul W. Finn; Morwena Bandara; Chris Butcher; Angela Finn; Ruth Hollinshead; Nag 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 German ⚖ 374 KB

## Abstract Inhibition of the enzyme histone deacetylase (HDAC) is emerging as a novel approach to the treatment of cancer. A series of novel sulfonamide derivatives were synthesized and evaluated for their ability to inhibit human HDAC. Compounds were identified which are potent enzyme inhibitors,