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Synthesis of side chain modified apicidin derivatives: potent mechanism-based histone deacetylase inhibitors

✍ Scribed by Peter T Meinke; Steven L Colletti; Michelle B Ayer; Sandra J Darkin-Rattray; Robert W Myers; Dennis M Schmatz; Matthew J Wyvratt; Michael H Fisher

Book ID: 104210915
Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 87 KB
Volume: 41
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)01364-2

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✦ Synopsis

An efficient degradation of apicidin's ketone-containing side chain to two common intermediates (the C7-aldehyde and the C8-methyl ester) is described. From these intermediates, a series of potent mechanism-based histone deacetylase inhibitors was prepared to facilitate biochemical studies.

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