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Synthesis and SAR Studies of Very Potent Imidazopyridine Antiprotozoal Agents.

โœ Scribed by Tesfaye Bifu; et al. et al.

Book ID
101994643
Publisher
John Wiley and Sons
Year
2006
Weight
13 KB
Volume
37
Category
Article
ISSN
0931-7597

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โœฆ Synopsis

Abstract

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A ruthenium tetraoxide catalyzed degradation of apicidin's tryptophan indole provided access to two useful carboxylic acid homolog intermediates. The synthesis of a series of potent and/or selective ketone homologs and 2-arylindoles derived from apicidin is described.