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Design and Synthesis of Highly Potent and Selective Melanotropin Analogues of SHU9119 Modified at Position 6

✍ Scribed by Paolo Grieco; Guoxia Han; David Weinberg; Tanya MacNeil; L.H.T. Van der Ploeg; Victor J. Hruby


Book ID
115589777
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
71 KB
Volume
292
Category
Article
ISSN
0006-291X

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We report here the solid-phase synthesis and vasodepressor potencies of a new lead vasopressin (VP) hypotensive peptide [1(beta-mercapto-beta,beta-pentamethylenepropionic acid)-2-0-ethyl-D-tyrosine, 3-arginine, 4-valine, 7-lysine, 9-ethylenediamine] lysine vasopressin, d(CH(2))(5)[D-Tyr(Et)(2), Arg(