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Design, synthesis, and biological activities of a potent and selective α-melanotropin antagonist

✍ Scribed by AL-OBEIDI, FAHAD ;HRUBY, VICTOR J. ;HADLEY, MAC E. ;SAWYER, TOMI K. ;CASTRUCCI, ANA M.


Book ID
115099066
Publisher
Wiley (Blackwell Publishing)
Year
2009
Tongue
English
Weight
588 KB
Volume
35
Category
Article
ISSN
0367-8377

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## Abstract Chemical synthesis and biological activities of a new α‐melanotropin derivative are described. __N__^α^‐(5‐Bromovaleryl)‐__N__^α^‐deacetyl‐α‐melanotropin contains the 5‐bromopentanoyl group as a chemical ‘handle’ in place of the acetyl group of the natural hormone. The synthesis involve

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## Abstract Asymmetric disulfide conjugates of mercaptosuccinyl tobacco mosaic virus (TMV ∼ SH) with __N__^α^‐desacetyl‐__N__^α^‐5‐(mercaptovaleryl)‐α‐melanotropin were prepared __via__ the __S__‐sulfoderivative of the peptide. The conjugates, TMV ∼ SS ∼ α‐MSH(__n__), contained up to __n__ = 330 d