Structure activity studies of the melanocortin antagonist SHU9119 modified at the 6, 7, 8, and 9 positions☆
✍ Scribed by Carrie Haskell–Luevano; Sejin Lim; Wei Yuan; Roger D Cone; Victor J Hruby
- Book ID
- 117409477
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 146 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0196-9781
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The exocyclic amino groups of deoxyadenosine and deoxyguanosine readily add to C-10 of the benzo[a]pyrene 7,8-diol 9,10-epoxides at room temperature overnight in trifluoroethanol. Whereas the dG adducts are obtained as a mixture of cis-and trans-opened diastereomers, the dA adducts arise exclusively
Reversed-phase high-performance liquid chromatography and capillary zone electrophoresis are widely used in protein and peptide analysis. Degradation of the basic peptide \(\left[\right.\) Arg \(^{6}\), D-Trp \({ }^{7,9}\), MePhe \(\left.^{8}\right]\)-substance P \(\{6-\) 11 (antagonist G) was monit