Tritium labelling of several potent fluorinated antipsychotic drugs at high specific activity
β Scribed by David G. Ahern; Anne G. Laseter; Crist N. Filer
- Book ID
- 103816972
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 154 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0969-8043
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## Department of Chemistry Labelled Compounds and Metabolite Synthesis Group 31, avenue Paul Vaillant-Couturier 92220 BAGNEUX (FRANCE) SmOuRY The synthesis of betaxolol, a new 8-blocking agent. labelled with tritium in high specific activity ('19 Ci/mmol) is described. The tritium was incorporated
Dz binding properties, i s described. The pyrrolidine moiety of the molecule i s labelled with tritium by hydrogenation, to a specific a c t i v i t y o f up to 58 Ci/mnol and subsequently reacted with an acid chloride. The specificity o f the label i s confirmed by 'H-"R.