𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Tritium and deuterium exchange-labeling of aromatic and organometallic compounds in heptafluorobutyric acid

✍ Scribed by Robert P. Hanzlik; Robert A. Wiley; Timothy J. Gillesse


Publisher
John Wiley and Sons
Year
1979
Tongue
French
Weight
279 KB
Volume
16
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Synthesis of deuterium and tritium label
✍ Peter J. Ramm; John B. Taylor 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 French ⚖ 323 KB 👁 1 views

## Abstract A new hepatoprotective agent, N‐(2‐hydroxyethyl)‐maleopimarimidyl morpholide (RU18492) has been synthesised labelled with tritium at C‐3, C‐4a, C‐10 and in the C‐isopropyl group. The incorporation of tritium relies on the acid‐catalysed isomerisation of levopimaric acid (4) to abietic a

Use of 2-dimethylaminopyridine in tritiu
✍ Guvvala N. Reddy; Christopher J. Soares; Mark J. Kurth; Hank J. Segall 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 142 KB

## Abstract Advantages of 2‐dimethylaminopyridine as base in isotope exchange reactions that occur via enol formation are described for the preparation of deuterium and tritium labeled hexanal.

Enzymatic synthesis of phenylpyruvic aci
✍ Katarzyna Skowera; Marianna Kańska 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 115 KB

## Abstract The synthesis of isotopomers of phenylpyruvic acid, PPA, selectively labeled with hydrogen isotopes in the 3‐position of the side‐chain is reported. Three deuterium or tritium labeled isotopomers of L‐phenylalanine, L‐Phe, i.e. [(3__S__)‐^2^H]‐L‐, [(3__S__)‐^3^H]‐L‐, and doubly labeled

Acid catalyzed tritium exchange of activ
✍ Richard R. Muccino; Lucia Serico 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 French ⚖ 131 KB

A technique is described for the acid catalyzed tritium exchange of activated aromatic protons using acetic acid-HI tritium chloride. In the two examples reported, specific activities of 0.5 Ci/rmnol were obtained for propranolol and 1.73 Ci/mmol for reserpine. be very effective and easily manipulat

Synthesis of labelled bioactive compound
✍ M. Stiasni; H. Stähle 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 French ⚖ 266 KB

## Abstract Five compounds of a group of 2‐(arylimino)‐imidazolidines, among them Clonidine (St 155), have been labeled with ^14^ in the following manner: Potassium cyanide‐[^14^C] was converted to potassium thiocyanate‐[^14^C] and subsequently to the N′‐phenylthiourea using benzoyl chloride and th

Synthesis of labelled histamine H2-recep
✍ T. Hesselbo; S. W. Slade; A. J. Villani; L. Petka 📂 Article 📅 1979 🏛 John Wiley and Sons 🌐 French ⚖ 323 KB

The H -antagonists, metiamide and cimetidine were labelled 2 with deuterium and tritium in the 2-position of the imidazole ring by the uncatalyzed exchange reaction with deuterium and tritium oxide at 100°C. The sulfur-35 labelled metiamide was prepared by an exchange reaction with elemental sulfur-