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Synthesis of deuterium and tritium labelled derivatives of maleopimaric acid

✍ Scribed by Peter J. Ramm; John B. Taylor

Publisher
John Wiley and Sons
Year
1976
Tongue
French
Weight
323 KB
Volume
12
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

A new hepatoprotective agent, N‐(2‐hydroxyethyl)‐maleopimarimidyl morpholide (RU18492) has been synthesised labelled with tritium at C‐3, C‐4a, C‐10 and in the C‐isopropyl group. The incorporation of tritium relies on the acid‐catalysed isomerisation of levopimaric acid (4) to abietic acid (2), which was then converted in three stages to (3).

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