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Synthesis of deuterium-labelled lithocholic acid

✍ Scribed by T. A. Baillie; M. Karls; J. Sjövall

Publisher
John Wiley and Sons
Year
1978
Tongue
French
Weight
375 KB
Volume
14
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

A convenient synthesis is reported of lithocholic acid labelled in high isotopic purity with two atoms of deuterium at C‐11. Incorporation of deuterium is achieved by base‐catalyzed equilibration of a 12‐oxo bile acid in heavy water. The product is converted in situ into its tosylhydrazone derivative which is reduced with sodium borohydride to afford the labelled 12‐deoxy bile acid.

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