Trisomies 8 and 20 in desmoid tumors
✍ Scribed by Heng Qi; Paola Dal Cin; Jesus M. Hernández; Juan Luis Garcia; Raf Sciot; Christopher Fletcher; Peter Van Eyken; Ivo De Wever; Herman Van Den Berghe
- Book ID
- 114136061
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 246 KB
- Volume
- 92
- Category
- Article
- ISSN
- 0165-4608
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Ten desmoid tumors were examined by chromosome banding analysis and by in situ hybridization on Short-term cultures and frozen sections. Trisomy 8 was detected in four out of ten tumors, of which only one had shown t r i m y 8 by karyotype analysis. Since trisomy 8 has been reported in superficial f
Cytogenetic analysis revealed trisomy 20 in 4 desmoid tumors: in 2 cases as the sole aberration, in I together with +X, -Y and -I 3 and in I with +8 and a supernumerary marker chromosome. Our findings indicate that gain of chromosome 20 is an early event in the development of a large subset of desmo