A total of 65 patients under the age of 55 with acute leukaemia received high-dose cytosine arabinoside (Ara-C) in combination with high-dose etoposide without an anthracycline. Complete remission rates for patients with relapsed or refractory acute myelogenous leukaemia (AML) were 15/25 (60%) and 1
TREATMENT OF REFRACTORY ACUTE LEUKAEMIA WITH HIGH DOSE CYTOSINE ARABINOSIDE
β Scribed by R. Willemze; F. E. Zwaan; J. J. Keuning; G. Colpin
- Book ID
- 114709737
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- English
- Weight
- 120 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0007-1048
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Clofarabine (40Β mg/m^2^/dayβΓβ5) and high-dose cytosine arabinoside (Ara-C, 1β2Β g/m^2^/dayβΓβ5) were used in 10 men and 11 women, at a median age of 45 (22β62)βyears, with refractory (__N__β=β4) and relapsed (__N__β=β17) acute myeloid leukaemia, after a median of 3 (2β5) prior regimens. Grade 4 myel
Thirteen leukemic patients with disease refractory to conventional chemotherapy were treated with 1.0 to 7.5 g/m2 of Cytosine Arabinoside (Ara-C) over 29 drug cycles. Drug infusions were spaced at 12-hour intervals; a maximum of four doses was administered over 36 hours. After single dose tolerance