High Dose Cytosine Arabinoside in the Management of Refractory Acute Leukaemia
β Scribed by Willemze, R. ;Zwaan, F. E. ;Colpin, G. ;Keuning, J. J.
- Book ID
- 114789786
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2009
- Weight
- 311 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0036-553X
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π SIMILAR VOLUMES
Thirteen leukemic patients with disease refractory to conventional chemotherapy were treated with 1.0 to 7.5 g/m2 of Cytosine Arabinoside (Ara-C) over 29 drug cycles. Drug infusions were spaced at 12-hour intervals; a maximum of four doses was administered over 36 hours. After single dose tolerance
A total of 65 patients under the age of 55 with acute leukaemia received high-dose cytosine arabinoside (Ara-C) in combination with high-dose etoposide without an anthracycline. Complete remission rates for patients with relapsed or refractory acute myelogenous leukaemia (AML) were 15/25 (60%) and 1
Clofarabine (40Β mg/m^2^/dayβΓβ5) and high-dose cytosine arabinoside (Ara-C, 1β2Β g/m^2^/dayβΓβ5) were used in 10 men and 11 women, at a median age of 45 (22β62)βyears, with refractory (__N__β=β4) and relapsed (__N__β=β17) acute myeloid leukaemia, after a median of 3 (2β5) prior regimens. Grade 4 myel
The development of resistance to Ara-C by leukemia cells may be a multifactorial process. These include diminished rates of anabolism or increased rate of catabolism to Ara-C, competition for incorporation into DNA by higher pool size of the competing normal metabolite, dCTP and perhaps other mechan
Forty-four patients with a diagnosis of refractory or relapsed acute myelogenous leukemia received salvage chemotherapy with high-dose cytosine arabinosine 3 g/m2 intravenously over 2 hours every 12 hours for six doses and mitoxantrone 5 mg/m2 intravenously daily for 5 days. Overall 16 patients (36%