Treatment of Refractory Adult Acute Lymphocytic Leukaemia and Acute Undifferentiated Leukaemia with an Anthracycline Antibiotic and Cytosine Arabinoside
β Scribed by Amy Papalia Early; H. D. Preisler; Arlin J. Gottlieb; Neil A. Lanchant
- Book ID
- 114709465
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- English
- Weight
- 501 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0007-1048
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π SIMILAR VOLUMES
A total of 65 patients under the age of 55 with acute leukaemia received high-dose cytosine arabinoside (Ara-C) in combination with high-dose etoposide without an anthracycline. Complete remission rates for patients with relapsed or refractory acute myelogenous leukaemia (AML) were 15/25 (60%) and 1
Clofarabine (40Β mg/m^2^/dayβΓβ5) and high-dose cytosine arabinoside (Ara-C, 1β2Β g/m^2^/dayβΓβ5) were used in 10 men and 11 women, at a median age of 45 (22β62)βyears, with refractory (__N__β=β4) and relapsed (__N__β=β17) acute myeloid leukaemia, after a median of 3 (2β5) prior regimens. Grade 4 myel
## Abstract ## BACKGROUND Drug resistance and early disease recurrence were major contributing factors in the limited survival of patients with acute lymphocytic leukemia (ALL). New chemotherapeutic agents and drug combinations were employed in refractory patients to overcome drug resistance. ##