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Treatment of refractory acute myeloid leukemia with high-dose cytosine arabinoside and mitoxantrone in combination

✍ Scribed by W. Hiddemann; H. Kreutzmann; W.D. Ludwig; H.C. Aul; R. Donhuijsen-Ant; E. Lengfelder; Th. Büchner


Book ID
113238657
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
92 KB
Volume
10
Category
Article
ISSN
0145-2126

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Mitoxantrone and high-dose cytosine arab
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Twenty-five adult patients with refractory acute lymphocytic leukemia received salvage therapy with mitoxantrone 5 mg/m2 intravenously over 1 hour daily for 5 days and cytosine arabinoside 3 g/m2 intravenously over 2 hours every 12 hours for six doses. Overall, nine patients (36%) achieved complete

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Thirteen leukemic patients with disease refractory to conventional chemotherapy were treated with 1.0 to 7.5 g/m2 of Cytosine Arabinoside (Ara-C) over 29 drug cycles. Drug infusions were spaced at 12-hour intervals; a maximum of four doses was administered over 36 hours. After single dose tolerance